The Ink4c and Ptch1 genes collaborate to suppress the development of the brain tumor medulloblastoma, according to a team led by St. Jude Children's Research Hospital investigators. The Ink4c and Ptch1 collaboration occurs independently of another anti-cancer collaboration: that of Ptch1 with the p53 gene, the researchers said.
The discovery sheds new light on how cells in the cerebellum called granule neuronal precursor cells (GNPs) give rise to medulloblastoma when certain genes are absent or functioning abnormally.
MORE... St. Jude Children's Research Hospital